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norskBlar i forfatter "Moldes-Anaya, Angel"
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Anxiolytic-like Effects of the Positive GABA-B Receptor Modulator GS39783 Correlate with Mice's Individual Basal Anxiety and Stress Reactivity
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-16)Positive gamma-aminobutyric acid type B (GABAB) receptor modulators such as GS39783 have showed anxiolytic-like effects in several studies while such effects were absent in other studies. These conflicting findings led us hypothesize that the anxiolytic-like effects of such compounds depend on the individual basal anxiety and/or the anxiogenic properties of the used tests. The present study ... -
Anxiolytic‐like Effects of the Positive GABAB Receptor Modulator GS39783 Correlate with Mice’s Individual Basal Anxiety and Stress Reactivity
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-16)Positive gamma-aminobutyric acid type B (GABAB) receptor modulators such as GS39783 have showed anxiolytic-like effects in several studies while such effects were absent in other studies. These conflicting findings led us hypothesize that the anxiolytic-like effects of such compounds depend on the individual basal anxiety and/or the anxiogenic properties of the used tests. The present study ... -
Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH‐receptor ligands for brain SPECT imaging
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)The increased expression of gonadotropin releasing hormone receptor (GnRH‐R) in brain has been strongly linked to Alzheimer disease. Therefore, the development of radiolabeled imaging agents for GnRH‐R is relevant for early diagnosis of Alzheimer disease. We have recently disclosed the discovery of two promising compounds displaying nanomolar‐range affinity for the GnRH‐R. In the present study, a ... -
Glioblastoma PET/MRI: kinetic investigation of [<sup>18</sup>F]rhPSMA-7.3, [<sup>18</sup>F]FET and [<sup>18</sup>F]fluciclovine in an orthotopic mouse model of cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-22)<b><p>Purpose</b> Glioblastoma multiforme (GBM) is the most common glioma and standard therapies can only slightly prolong the survival. Neo-vascularization is a potential target to image tumor microenvironment, as it defines its brain invasion. We investigate [<sup>18</sup>F]rhPSMA-7.3 with PET/MRI for quantitative imaging of neo-vascularization in GBM bearing mice and human tumor tissue and compare ... -
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-04)Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in consumer products. PFAAs cross the blood-brain-barrier and have been observed to induce adverse neurobehavioural effects in humans and animals as well as adverse effects in neuronal in ... -
Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-25)The peroxisome proliferator-activated receptors (PPARs) function as ligand-activated transcription factors that convert signals in the form of lipids to physiological responses through the activation of metabolic target genes. Due to their key roles in lipid and carbohydrate metabolism, the PPARs are important drug targets. However, for several of the PPAR drugs currently in use, adverse side effects ...
